Dexamethasone Impurity 5(Dexamethasone EP Impurity E)

Name	Vamorolone
Synonyms	VBP15 Vamorolone Dexamethasone impurity E Dexamethasone Impurity L (8S,10S,13S,14S,16R,17R)-17-hydroxy 16α-Methyl-9,11-dehydro Prednisolone Dexamethasone Impurity 5(Dexamethasone EP Impurity E) 17,21-dihydroxy-16alpha-methylpregna-1,4,9(11)-triene-3,20-dione (16α)-17,21-Dihydroxy-16-Methylpregna-1,4,9(11)-triene-3,20-dione 17.alpha.,21-Dihydroxy-16.alpha.-methylpregna-1,4,9(11)-triene-3,20-dione
CAS	13209-41-1
EINECS	236-177-8

Molecular Formula	C22H28O4
Molar Mass	356.46
Density	1.24±0.1 g/cm3(Predicted)
Melting Point	228-231 °C(Solv: acetone (67-64-1); hexane (110-54-3))
Boling Point	548.3±50.0 °C(Predicted)
Solubility	Chloroform (Slightly), Dioxane (Slightly), Ethyl Acetate (Slightly)
Appearance	Solid
Color	Pale Yellow
pKa	12.53±0.70(Predicted)
Storage Condition	Refrigerator
In vitro study	Vamorolone (VBP15) inhibits TNFα-induced pro-inflammatory NF-κB signaling in C2C12 muscle cells at 1 nM or more. Vamorolone binds the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) with similar affinity. Vamorolone (0.1, 1μM; 30 minutes) reduces production of IL1βand CCL5 inflammatory mediators in primary human macrophages. Vamorolone is a first-in-class mineralocorticoid receptor (MR) antagonist/dissociative glucocorticoid receptor (GR) ligand.